2022’s Speaker: Wolfgang Baumeister
Professor, Max Planck Institute of Biochemistry
Cryo-Electron Tomography or the Power of Seeing the Whole Picture
Traditionally, structural biologists have approached cellular complexity in a reductionist manner by characterizing isolated and purified molecular components. This ‘divide and conquer’ approach has been highly successful. However, awareness has grown in recent years that only rarely can biological functions be attributed to individual macromolecules. Most cellular functions arise from their acting in concert. Hence there is a need for methods developments enabling studies performed in situ, i.e. in unperturbed cellular environments. Sensu stricto the term ‘structural biology in situ’ should apply only to a scenario in which the cellular environment is preserved in its entirety. Cryo electron tomography has unique potential to study the supramolecular architecture or ‘molecular sociology’ of cells. It combines the power of three-dimensional imaging with the best structural preservation that is physically possible.
Wolfgang Baumeister is a molecular biologist and biophysicist at the Max Planck Institute of Biochemistry’ who does research involving molecular biological structures, protein and cell structure, and protein degradation. His research has been pivotal in the development of Cryoelectron tomography. He has won many prizes, including the Otto Warburg Medal, the Louis-Jeantet Prize, the I. & H. Wachter Award, the Harvey Prize, the Schleiden Medal, the Ernst Schering Prize, and the Ernst Jung Gold Medal for Medicine.
Date & Time:
3 PM June 27, 2022
Reception and refreshments to follow
DeLuca Forum, Wisconsin Institutes for Discovery (WID)
The Center for Quantitative Cell Imaging (CQCI) at the University of Wisconsin-Madison hosts an annual seminar series honoring Hans Ris, who oversaw the installation of one of the nation’s first high-voltage electron microscopes in the former location of LOCI. Ris remained Emeritus Investigator of the IMR until his passing in 2004.
Co-sponsored by the Morgridge Institute for Research and the Center for Quantitative Cell Imaging
2019: Davi Bock, HHMI
2018: Tatyana Svitkina, University of Pennsylvania
2017: Erik M. Jorgensen, University of Utah
2016: David H. Hall, Albert Einstein College
2015: Kent McDonald, UC Berkeley
2014: Wah Chiu, Baylor College of Medicine
2013: Thomas Müller-Reichert, Technische Universität Dresden
2012: Mark E. Ellisman, UC San Diego